FACS machine by Kawamoto

 

publications

research articles

  1. QFMatch: multidimensional flow and mass cytometry samples alignment. Orlova D, Meehan S, Parks D, Moore W, Meehan C, Zhao Q, Ghosn EE, Herzenberg L, Walther G. Sci Rep. 2018 (in press)
  2. Evidence for altered levels of IgD in the nasal airway mucosa of patients with chronic rhinosinusitis. Min J, Raju P, Hulse K, Stevens W, Huang J, Van Roey G, Norton J, Suh L, Carter R, Price C, Weibman A, Rashan A, Ghosn EE, Homma T, Conley D, Welch K, Shintani-Smith S, Peters A, Grammer III L, Harris K, Kato A, Hwang P, Kern R, Herzenberg L, Schleimer R, Nayak J, Tan B. JACI 2017
  3. Fetal hematopoietic stem cell transplantation fails to fully regenerate the B-lymphocyte compartment. Ghosn EE*, Waters, J, Phillips M, Yamamoto R, Long B, Yang Y, Gerstein R, Stoddart C, Nakauchi H, Herzenberg, LA.  Stem Cell Reports 2016  *corresponding author | recommended in F1000 prime
  4. Earth Mover's Distance (EMD): a true metric for comparing biomarker expression levels in cell populations. Orlova D, Zimmerman N, Meehan S, Meehan C, Waters J, Ghosn EE, Filatenkov A, Kolyagin G, Gernez Y, Moss R, Herzenberg LA, Walther G. PLoS One 2016
  5. Characterization of immunoglobulin E plasma cells that are elevated in the upper airway mucosa of nonatopic patients with chronic rhinosinusitis without nasal polyps.Rashan A, Ghosn EE, Peterson A, Yang Y, Phillips M, Sahaf B, Herzenberg LA, Nayak JV. Int Forum Allergy Rhinol. 2016
  6. Amyloid fibrils activate B-1a lymphocytes to ameliorate inflammatory brain disease. Kurnellas MP, Ghosn EE, Schartner JM, Baker J, Rothbard J, Negrin R, Herzenberg LA, Fathman CG, Steinman L, Rothbard JB. PNAS 2015
  7. Distinct mechanisms define murine B cell lineage immunoglobulin heavy chain (IgH) repertoires. Yang Y, Wang C, Yang Q, Kantor AB, Chu H, Ghosn EE, Qin G, Mazmanian SK, Han J, Herzenberg LA. eLife 2015
  8. Selective uptake of single-walled carbon nanotubes by circulating monocytes for enhanced tumour delivery. Smith B, Ghosn EE, Rallapalli H, Prescher J, Herzenberg LA, Gambhir SS. Nature Nanotech. 2014
  9. AutoGate: automating analysis of flow cytometry data. Meehan S, Walther G, Moore W, Orlova D, Meehan C, Parks D, Ghosn EE, Philips M, Mitsunaga E, Waters J, Kantor A, Okamura R, Owumi S, Yang Y, Herzenberg LA and Herzenberg LA. Immunol Res. 2014
  10. Intracellular localization of myeloperoxidase in murine peritoneal B-lymphocytes and macrophages. Araujo T, Okada S, Ghosn EE, Taniwaki NN, Rodrigues MR, Almeida SR, Mortara RA, Russo M, Campa A, Albuquerque RC. Cell Immunol. 2013
  11. Reversal of Paralysis and Reduced Inflammation from Peripheral Administration of β-Amyloid in TH1 and TH17 Versions of Experimental Autoimmune Encephalomyelitis. Grant J, Ghosn EE, Axtell RC, Herges K, Kuipers HF, Woodling NS, Andreasson K, Herzenberg LA, Herzenberg LA, Steinman L. Sci Transl Med. 2012 | selected for the magazine cover
  12. Distinct B-cell lineage commitment distinguishes adult bone marrow hematopoietic stem cells. Ghosn EE*, Yamamoto R, Hamanaka S, Yang Y, Herzenberg LA, Nakauchi H, Herzenberg LA. PNAS 2012 *corresponding author | highlighted in In This Issue of PNAS
  13. Development of B cells and erythrocytes is specifically impaired by the drug celastrol in mice. Kusy S, Ghosn EE, Herzenberg LA, Contag CH. PLoS One 2012
  14. Antigen-specific memory in B-1a and its relationship to natural immunity. Yang Y, Ghosn EE, Cole LE, Obukhanych TV, Sadate-Ngatchou P, Vogel SN, Herzenberg LA, Herzenberg LA. PNAS 2012
  15. Antigen-specific antibody responses in B-1 and their relationship to natural immunity. Yang Y, Ghosn EE, Cole LE, Obukhanych TV, Sadate-Ngatchou P, Vogel SN, Herzenberg LA, Herzenberg LA. PNAS 2012
  16. Cellular renewal and improvement of local cell effector activity in peritoneal cavity in response to infectious stimuli. Cassado A, de Albuquerque J, Sardinha L, Buzzo CL, Faustino L, Nascimento R, Ghosn EE, Lima MR, Alvarez JM, Bortoluci KR. PLoS One 2011
  17. Distinct progenitors for B-1 and B-2 cells are present in adult mouse spleen. Ghosn EE*, Sadate-Ngatchou P, Yang Y, Herzenberg LA, Herzenberg LA. PNAS 2011 *corresponding author
  18. Basophil CD203c levels are increased at baseline and can be used to monitor omalizumab treatment in subjects with nut allergy. Gernez Y, Tirouvanziam R, Yu G, Ghosn EE, Reshawmala N, Nguyen T, Tsai M, Galli SJ, Herzenberg LA, Nadeau KC. Int Arch Allergy Immunol. 2011
  19. Two physically, functionally and developmentally distinct peritoneal macrophage subsets. Ghosn EE*, Cassado A, Govoni G, Fukuhara T, Yang Y, Monack D, Bortoluci K, Almeida SR, Herzenberg LA. PNAS 2010 *corresponding author
  20. Monocyte-derived dendritic cells from patients with severe forms of chromoblastomycosis induce CD4+ T cell activation in vitro. Sousa MG, Ghosn EE, Nascimento RC, Bomfim GF, Noal V, Santiago K, Silva Azevedo CM, Marques SG, Gonçalves AG, Lima Santos DW, Criado PR, Costa Martins JE, Almeida SR. Clin Exp Immunol. 2009
  21. CD11b expression distinguishes sequential stages of peritoneal B-1 development. Ghosn EE, Yang Y, Tung J, Herzenberg LA. PNAS 2008
  22. Fonsecaea pedrosoi infection induces differential modulation of co-stimulatory molecules and cytokines in monocytes from patients with severe and mild forms of chromoblastomycosis. Sousa MG, Azevedo C, Nascimento R, Ghosn EE, Santiago KL, Noal V, Bomfim GF, Marques SG, Gonçalves AG, Wagner de Castro D, Almeida SR. J Leukoc Biol. 2008
  23. Division and differentiation of natural antibody-producing cells in mouse spleen. Yang Y, Tung J, Ghosn EE, Herzenberg LA. PNAS 2007
  24. Absence of CD4+ T cells impairs host defense of mice infected with Fonsecaea pedrosoi. Sousa MG, Ghosn EE, Almeida SR. Scand J Immunol. 2006
  25. Phagocytosis, production of nitric oxide and pro-inflammatory cytokines by macrophages in the presence of dematiaceous fungi that cause chromoblastomycosis. Hayakawa M, Ghosn EE, Sousa MG, Ferreira KS, Almeida SR. Scand J Immunol. 2006
  26. Nitric oxide-dependent killing of Cryptococcus neoformans by B-1 derived mononuclear phagocyte. Ghosn EE, Russo M, Almeida SR. J Leukoc Biol. 2006

 

review articles
  1. B-1 Cell Development and Function. Rothstein TL, Herzenberg LA, Holodick NE, Ghosn E. Ann NY Acad Sci. 2015
  2. Hematopoietic stem cell-independent B-1a lineage. Ghosn EE* & Yang Yang. Ann NY Acad Sci. 2015 *corresponding author

 

book chapters

  1. Autogate, an automated approach to flow data analysis | pages 260-265. Herzenberg LA, Meehan S, Walther G, Parks D, Moore W, Meehan C, Philips M, Ghosn EE, Herzenberg LA.  In: Jikiden Flow Cytometry, First Edition, Yodosha Co., Ltd. Tokyo, Japan, 2014
  2. Severe Mycosis (Micoses Profundas) | pages 94-104. Ghosn EE. In: Micologia, First Edition, Guanabara Koogan S.A., Rio de Janeiro, Brazil, 2008
  3. Opportunistic Mycosis (Micoses Oportunistas) | pages 105-122. Ghosn EE. In: Micologia, First Edition, Guanabara Koogan S.A., Rio de Janeiro, Brazil, 2008